| Paperboy 2 | 1991 | Tengen |
| Parasol Henbē: Niji no Daibōken | 1990 | — |
| Penguin Wars | 1985 | UPL |
| Pinball Dreams | 1992 | DICE |
| Pinball Mania | 1995 | — |
| Pinocchio | 1996 | Bit Managers |
| Plotting | 1989 | Taito |
| Pocket Bomberman | 1997 | Hudson Soft |
| Pocket Love | 1997 | KID |
| Pocket Love 2 | — | KID |
| Pokémon Blue | 1996 | Game Freak |
| Pokémon Green | 1996 | Game Freak |
| Pokémon Red | 1996 | Game Freak |
| Pokémon Yellow | 1998 | Game Freak |
| Pop'n TwinBee | 1990 | — |
| Popeye | 1990 | — |
| Popeye 2 | 1991 | — |
| Populous | 1989 | Bullfrog Productions |
| Power Pro GB | 1998 | Konami Computer Entertainment Studio |
| Power Pro Kun Pocket | 1999 | Konami Computer Entertainment Studio, Pawapuro Production |
| Power Racer | 1990 | — |
| Prehistorik 2 | 1993 | Titus Interactive |
| Primal Rage | 1995 | Atari Games |
| Q*bert | 1982 | Atari |
| Q15875495 | 1992 | — |
| Q65228476 | 1994 | — |
| QBillion | 1989 | SETA Corporation |
| Qix | 1981 | Taito |
| Race Days | 1994 | Gremlin Interactive |
| Racing Damashii | 1991 | Irem |
| Raging Fighter | 1993 | Konami |
| Ranma ½ | 1990 | Banpresto |
| Rats! | 1998 | — |
| Revelations: The Demon Slayer | 1992 | — |
| Revenge of the 'Gator | 1989 | HAL Laboratory |
| Road Rash | 1994 | Electronic Arts |
| Roadster | 1990 | Tose Co. |
| Robin Hood: Prince of Thieves | 1991 | Sculptured Software |
| RoboCop | 1988 | Data East, Nichibutsu |
| Rolan's Curse | 1990 | Sammy Corporation |
| Rolan's Curse II | 1992 | — |
| Ruby & Rusty – Save the Crows | 2021 | — |
| Saint Paradise | 1992 | — |
| Samurai Shodown | 1993 | SNK |
| Satoru Nakajima F-1 Hero GB World Championship '91 | 1991 | — |
| SD Gundam Gaiden: Knight Gundam Monogatari | 1990 | Tose Co. |
| SD Gundam Gaiden: Knight Gundam Monogatari 3 - Densetsu no Kishi Dan | 1992 | Bandai |
| SD Gundam Gaiden: Lacroan Heroes | 1990 | Bandai |
| SD Gundam: SD Sengokuden - Kunitori Monogatari | 1990 | Bandai |
| SD Gundam: SD Sengokuden 2 - Tenka Touitsu Hen | 1992 | Bandai |
| SD Gundam: SD Sengokuden 3 - Chijou Saikyou Hen | 1992 | Bandai |
| SD Rupan Sansei - Kinko yaburi daisakusen | 1990 | — |
| Serpent | 1990 | Kaga Create |
| Shamus | 1982 | — |
| Shaq Fu | 1994 | Delphine Software International |
| Shin SD Gundam Gaiden | 1994 | — |
| Shin SD Gundam Gaiden: Knight Gundam Monogatari | 1994 | Bandai |
| Shippū! Iron Leaguer | 1994 | — |
| Shuyaku Sentai Irem Fighter | 1993 | Irem |
| Shōgi Saikyō | 1994 | — |