| SPOGS Racing | 2008 | Pronto Games |
| SpongeBob SquarePants featuring Nicktoons: Globs of Doom | 2008 | Incinerator Studios |
| SpongeBob SquarePants: Creature from the Krusty Krab | 2006 | Blitz Games |
| SpongeBob SquarePants: Plankton's Robotic Revenge | 2013 | Behaviour Interactive |
| SpongeBob SquigglePants | 2011 | WayForward Technologies |
| SpongeBob's Atlantis SquarePantis | 2007 | Blitz Games |
| SpongeBob's Boating Bash | 2010 | Firebrand Games |
| SpongeBob's Truth or Square | 2009 | Heavy Iron Studios |
| Spore Hero | 2009 | EA Montreal |
| SPRay | 2008 | Eko Software |
| Springdale: Riding Adventures | 2010 | Pixel Tales, Hidden Entertainment |
| Spy Fox in "Dry Cereal" | 1997 | Humongous Entertainment |
| Spy Games: Elevator Mission | 2007 | Dreams Co., Ltd. |
| Spyborgs | 2009 | Bionic Games |
| SSX Blur | 2007 | EA Montreal |
| Star Fox 64 | 1997 | Nintendo Entertainment Analysis & Development |
| Star Trek: Conquest | 2007 | 4J Studios |
| Star Wars: The Clone Wars – Lightsaber Duels | 2008 | Krome Studios |
| Star Wars: The Clone Wars – Republic Heroes | 2009 | Krome Studios |
| Star Wars: The Force Unleashed | 2008 | Lucasfilm Games |
| Star Wars: The Force Unleashed II | 2010 | Lucasfilm Games |
| Street Fighter II | 1991 | Capcom |
| Street Football 2 | 2009 | Dehon Games |
| Strider | 1989 | Capcom |
| Strong Bad's Cool Game for Attractive People: Season 1 | 2008 | Telltale Games |
| Strong Badia the Free | 2008 | Telltale Games |
| Stubbs the Zombie in Rebel Without a Pulse | 2005 | Wideload Games |
| Stunt Flyer: Hero of the Skies | 2010 | Nice Ideas |
| Sudoku Challenge! | 2008 | Digital Leisure |
| Sudokuball Detective | 2009 | White Bear BV, CreaVate |
| Sukeban Shachou Rena | 2009 | Jorudan |
| Summer Athletics | 2008 | 49Games |
| Summer Athletics 2009 | 2009 | 49Games |
| Summer Sports: Paradise Island | 2008 | Destineer |
| Super Famicom Wars | 1998 | Intelligent Systems |
| Super Fruit Fall | 2006 | Aqua Pacific |
| Super Mario 128 | — | Nintendo Entertainment Analysis & Development |
| Super Mario All-Stars | 1993 | Nintendo Entertainment Analysis & Development, Nintendo |
| Super Mario All-Stars 25th Anniversary Edition | 2010 | Nintendo Entertainment Analysis & Development |
| Super Mario Galaxy | 2007 | Nintendo Entertainment Analysis & Development |
| Super Mario Galaxy 2 | 2010 | Nintendo Entertainment Analysis & Development |
| Super Mario RPG | 1996 | Square |
| Super Mario World | 1990 | Nintendo Entertainment Analysis & Development |
| Super Metroid | 1994 | Nintendo Research & Development 1 |
| Super Monkey Ball: Banana Blitz | 2006 | Sega |
| Super Monkey Ball: Step & Roll | 2010 | Sega |
| Super Paper Mario | 2007 | Intelligent Systems |
| Super Robot Wars NEO | 2009 | Banpresto |
| Super Sentai Battle: Ranger Cross | 2011 | Bandai Namco Entertainment |
| Super Smash Bros. Brawl | 2008 | Sora Ltd. |
| Super Sonic Racer | 2011 | Team6 Game Studios |
| Super Star Kartz | 2011 | High Impact Games |
| Super Star Wars | 1992 | Lucasfilm Games, Code Mystics, Sculptured Software |
| Super Star Wars: Return of the Jedi | 1994 | Realtime Associates, Sculptured Software |
| Super Star Wars: The Empire Strikes Back | 1993 | Lucasfilm Games, Sculptured Software |
| Super Swing Golf | 2006 | Ntreev Soft |
| Super Swing Golf: Season 2 | 2007 | Tecmo |
| Surf's Up | 2007 | Ubisoft Montreal |
| Swords & Soldiers | 2009 | Ronimo Games |
| Taiko no Tatsujin Wii | 2008 | Namco |