| Shaun White Snowboarding | 2008 | Ubisoft Montreal |
| Shaun White Snowboarding: Road Trip | 2008 | 2K China |
| Shaun White Snowboarding: World Stage | 2009 | Ubisoft Montreal |
| Sherlock Holmes: The Mystery of the Mummy | 2002 | Frogwares |
| Shimano Xtreme Fishing | 2009 | EV Interactive |
| Shiren the Wanderer | 2008 | Chunsoft |
| Showtime Championship Boxing | 2007 | Nikitova Games |
| Shrek Forever After | 2010 | XPEC Entertainment |
| Shrek the Third | 2007 | Shaba Games |
| Shrek's Carnival Craze | 2008 | Nordcurrent |
| Sid Meier's Pirates! | 2004 | Firaxis Games |
| Silent Hill: Shattered Memories | 2009 | Climax Studios |
| Silver Star Chess | 2008 | Agetec |
| Silver Star Reversi | 2008 | Agetec |
| Sim City | 1991 | Electronic Arts |
| SimAnimals | 2009 | Electronic Arts |
| SimCity | 1989 | Nintendo Entertainment Analysis & Development, Maxis |
| SimCity Creator | 2008 | Hudson Soft |
| SimEarth | 1990 | Maxis |
| Simple Series Vol. 4: The Misshitsu kara no Dasshutsu | 2009 | INTENSE |
| Sin & Punishment: Star Successor | 2009 | Treasure |
| Skate It | 2008 | EA Montreal |
| Ski-Doo: Snowmobile Challenge | 2009 | Coldwood Interactive |
| Skylanders: Giants | 2012 | Toys for Bob |
| Skylanders: Spyro's Adventure | 2011 | Toys for Bob |
| Skylanders: Swap Force | 2013 | Blizzard Albany |
| Sled Shred featuring the Jamaican Bobsled Team | 2010 | — |
| Smarty Pants | 2007 | Planet Moon Studios |
| Sniper Elite | 2005 | Rebellion Developments |
| SNK Arcade Classics Vol. 1 | 2008 | Terminal Reality |
| Snowboard Riot | 2009 | Hudson Soft |
| Snowpack Park | 2010 | skip Ltd. |
| So Blonde | 2008 | Wizarbox |
| So Blonde: Back to the Island | 2010 | Wizarbox |
| Solvalou | 1991 | Namco |
| Sonic & Knuckles | 1994 | Sonic Team |
| Sonic & Sega All-Stars Racing | 2010 | Sumo Digital |
| Sonic and the Black Knight | 2009 | Sonic Team |
| Sonic and the Secret Rings | 2007 | Sonic Team |
| Sonic Colors | 2010 | Sonic Team |
| Sonic Riders: Zero Gravity | 2008 | Sonic Team |
| Sonic the Hedgehog | 1991 | Sonic Team, Konami |
| Sonic the Hedgehog 4: Episode I | 2010 | Sonic Team |
| Sonic Unleashed | 2008 | Sonic Team |
| Sorcerian | 1987 | Aeria, Nihon Falcom, Sega, G-Mode |
| Sorcery Blade | 2008 | WorldWideSoftware |
| Soul Eater: Monotone Princess | 2008 | Square Enix |
| Soulcalibur Legends | 2007 | Project Soul |
| Space Chimps | 2008 | Redtribe |
| Space Invaders Get Even | 2008 | Taito |
| Space Invaders: Fukkatsu no Hi | 1990 | Taito |
| Space Station Tycoon | — | Wahoo Studios |
| Spaceball Revolution | 2009 | Virtual Toys |
| Spectrobes: Origins | 2009 | Genki |
| Speed Racer: The Videogame | 2008 | Sidhe |
| Spider-Man 3 | 2007 | Blizzard Albany, Treyarch |
| Spider-Man: Edge of Time | 2011 | Beenox |
| Spider-Man: Friend or Foe | 2007 | Next Level Games |
| Spider-Man: Shattered Dimensions | 2010 | Beenox |
| Spider-Man: Web of Shadows | 2008 | Shaba Games |