| Rock Band 3 | 2010 | Harmonix Music Systems, Backbone Emeryville |
| Rock Band Metal Track Pack | 2009 | Harmonix Music Systems |
| Rock Band: Country Track Pack | 2009 | Harmonix Music Systems |
| Rock Band: Country Track Pack 2 | 2011 | Harmonix Music Systems |
| Rock Band: Track Pack - Volume 1 | 2008 | Harmonix Music Systems |
| Rock Band: Track Pack - Volume 2 | 2008 | Harmonix Music Systems |
| Rock Revolution | 2008 | Zoë Mode |
| Rockstar Games presents Table Tennis | 2006 | Rockstar San Diego |
| Rodea the Sky Soldier | 2015 | Prope |
| Rogue Trooper | 2006 | Rebellion Developments |
| Rolling Stone: Drum King | 2009 | 505 Games |
| Romance of the Three Kingdoms XI | 2006 | Koei |
| Rooms: The Main Building | 2008 | Hudson Soft |
| Rotohex | 2008 | skip Ltd. |
| Rotozoa | 2010 | skip Ltd. |
| Rubik's Puzzle World | 2008 | Two Tribes |
| Rudolph the Red-Nosed Reindeer | 2010 | High Voltage Software |
| Rugby League 3 | 2010 | Sidhe |
| Runaway 2: The Dream of the Turtle | 2006 | Pendulo Studios, S.L. |
| Rune Factory Frontier | 2008 | Neverland |
| Rune Factory: Tides of Destiny | 2011 | Neverland |
| Rygar: The Legendary Adventure | 2002 | Tecmo |
| Sadness | — | Nibris |
| Safecracker: The Ultimate Puzzle Adventure | 2006 | Kheops Studio |
| Sakura Wars: So Long, My Love | 2005 | Sega, Idea Factory, Red Entertainment |
| Sam & Max Beyond Time and Space | 2007 | Telltale Games |
| Sam & Max Save the World | 2006 | Telltale Games |
| Sam & Max: Ice Station Santa | 2007 | Telltale Games |
| Samba de Amigo | 2000 | Sonic Team |
| SameGame | 1985 | Hudson Soft |
| Samurai Shodown Anthology | 2008 | SNK |
| Samurai Shodown VI | 2005 | SNK |
| Samurai Warriors 3 | 2009 | Koei Tecmo Holdings |
| Samurai Warriors: Katana | 2007 | Koei Tecmo Holdings |
| Sandy Beach | 2009 | Frozen Codebase |
| Scarface: The World Is Yours | 2006 | Radical Entertainment |
| Scene It? Bright Lights! Big Screen! | 2009 | Behaviour Interactive |
| Scene It? Twilight | 2009 | Paramount Digital Entertainment |
| Schlag den Raab | 2010 | Sproing Interactive Media |
| Schlag den Raab: Das 2. Spiel | 2011 | Sproing Interactive Media |
| Scooby-Doo! and the Spooky Swamp | 2010 | Torus Games |
| Scooby-Doo! First Frights | 2009 | Torus Games |
| SCORE International Baja 1000 | 2008 | Left Field Productions |
| SD Gundam World: Gachapon Senshi - Scramble Wars | 1987 | Bandai |
| SD Gundam: G Generation Wars | 2009 | Bandai |
| SD Gundam: Scad Hammers | 2006 | Bandai |
| Sea Monsters: A Prehistoric Adventure | 2007 | Atomic Planet Entertainment |
| Secret Files 2: Puritas Cordis | 2009 | Animation Arts |
| Secret Files: Tunguska | 2006 | Animation Arts |
| Secret of Mana | 1993 | Square |
| Sega Bass Fishing | 1999 | Sega Wow |
| Sega Superstars Tennis | 2008 | Sumo Digital |
| Sengoku Basara 2 | 2006 | Capcom |
| Sengoku Basara 3 Utage | 2011 | Capcom |
| Sexy Poker | 2009 | Gameloft |
| ShadowPlay | 2010 | Deep Fried Entertainment |
| Shake It Up | 2011 | Papaya Studio |
| Shake It Up 2: Groove It Up | 2012 | Papaya Studio |
| Shakedown: Hawaii | 2019 | Vblank Entertainment |
| Shaun White Skateboarding | 2010 | Ubisoft Montreal |