| Smash Tennis | 1993 | Namco |
| Smash TV | 1990 | WMS Industries |
| Snoopy Concert | 1995 | Pax Softnica |
| Snow White: Happily Ever After | 1994 | ASC Games |
| Soccer Kid | 1993 | Krisalis Software |
| Socks the Cat Rocks the Hill | 1993 | Kaneko |
| Solid Runner | 1997 | Sting |
| Song Master | 1992 | Japan Art Media |
| Sonic Blast Man | 1992 | Taito |
| Sonic Blast Man II | 1994 | — |
| Sonic the Hedgehog 4 | 1996 | — |
| Soreyuke Ebisumaru Karakuri: Meiro Kieta Goemon no Nazo | 1996 | — |
| SOS | 1993 | Human Entertainment |
| Sougou Kakutougi Rings: Astral Bout 3 | 1995 | — |
| Sougou Kakutougi: Astral Bout 2 - The Total Fighters | 1994 | — |
| Soukou Kihei Votoms: The Battling Road | 1993 | — |
| Soul & Sword | 1993 | — |
| Soul Blazer | 1992 | Quintet |
| Sound Fantasy | — | Nintendo |
| Sound Novel Tsukūru | 1996 | Success, ASCII Corporation |
| Space Ace | 1984 | RDI Video Systems |
| Space Ace | 1994 | Oxford Digital Enterprises Ltd |
| Space Football: One on One | 1992 | Bits Studios |
| Space Invaders | 1978 | Taito |
| Space Invaders DX | 1994 | — |
| Space Megaforce | 1992 | Compile |
| Spanky's Quest | 1991 | Winning Entertainment Group |
| Sparkster | 1994 | Konami |
| Sparkster: Rocket Knight Adventures 2 | 1994 | Konami |
| Spear of Destiny | 1992 | id Software |
| Spectre | 1991 | — |
| Speed Racer in My Most Dangerous Adventures | 1994 | Radical Entertainment |
| Speedy Gonzales: Los Gatos Bandidos | 1995 | Sunsoft |
| Spellcraft: Aspects of Valor | 1992 | — |
| Spider-Man and the X-Men in Arcade's Revenge | 1993 | Software Creations |
| Spider-Man and Venom: Maximum Carnage | 1994 | Software Creations |
| Spider-Man Animated Series | 1995 | — |
| Spindizzy Worlds | 1992 | — |
| Spirou | 1995 | Infogrames |
| Sports Illustrated: Championship Football & Baseball | 1993 | Malibu Comics |
| Spriggan Powered | 1996 | Micronics |
| Sprinter Monogatari: Mezase!! Ikkaku Senkin | 1995 | VAP Inc. |
| St Andrews: Eikō to Rekishi no Old Course | 1995 | — |
| Star Fox | 1993 | Nintendo Entertainment Analysis & Development, Argonaut Games |
| Star Fox 2 | 2017 | Nintendo |
| Star Fox: Super Weekend | 1993 | Nintendo Entertainment Analysis & Development, Argonaut Games |
| Star Ocean | 1996 | tri-Ace |
| Star Trek: Deep Space Nine – Crossroads of Time | 1995 | Appaloosa Interactive |
| Star Trek: Starfleet Academy – Starship Bridge Simulator | 1994 | High Voltage Software |
| Star Trek: The Next Generation: Future's Past | 1994 | Spectrum HoloByte |
| Stargate | 1994 | Acclaim Studios London |
| Stealth | 1992 | — |
| Steel Talons | 1991 | Atari Games |
| Sterling Sharpe: End 2 End | 1995 | Tose Co. |
| Stone Protectors | 1994 | Eurocom |
| Street Fighter Alpha 2 | 1996 | Capcom |
| Street Fighter II | 1991 | Capcom |
| Street Fighter II Turbo | 1992 | Capcom |
| Street Fighter II: Champion Edition | 1992 | Capcom |
| Street Hockey '95 | 1994 | GTE Interactive Media |