| Dragon Fighter | 1990 | Winning Entertainment Group |
| Dragon Power | 1986 | Bandai |
| Dragon Quest | 1986 | Chunsoft |
| Dragon Quest II | 1987 | Chunsoft |
| Dragon Quest III | 1988 | Chunsoft |
| Dragon Quest IV | 1990 | Chunsoft |
| Dragon Scroll | 1987 | Konami |
| Dragon Spirit: The New Legend | 1989 | Namco |
| Dragon Wars | 1991 | Interplay Entertainment |
| Dragon's Lair | 1990 | Motivetime Ltd. |
| Dragons of Flame | 1989 | U.S. Gold |
| DragonStrike | 1992 | Westwood Studios, Pony Canyon |
| Dream Master | 1992 | Birthday |
| Dreamworld Pogie | 2016 | Oliver Twins |
| Dropzone | 1984 | Archer Maclean |
| Duck | 1987 | Bit Corporation |
| Duck Hunt | 1984 | Nintendo Research & Development 1 |
| DuckTales | 1989 | Capcom |
| DuckTales 2 | 1993 | Capcom |
| Dungeon Kid | 1990 | Quest |
| Dungeon Magic: Sword of the Elements | 1989 | Winning Entertainment Group |
| Dusty Diamond's All-Star Softball | 1989 | Tose Co. |
| Dynamite Bowl | 1987 | Soft Vision International |
| Dynowarz: Destruction of Spondylus | 1990 | Advance Communication |
| Déjà Vu | 1985 | ICOM Simulations |
| Eggerland – Revival of the Labyrinth | 1988 | HAL Laboratory |
| Egypt | 1991 | Human Entertainment |
| Elevator Action | 1983 | Taito |
| Eliminator Boat Duel | 1991 | Sculptured Software |
| Elite | 1984 | David Braben, Ian Bell |
| Empire City: 1931 | 1987 | Seibu Kaihatsu |
| Erika to Satoru no Yume Bōken | 1988 | Atlus |
| Erunaaku no Zaihou | 1987 | Towa Chiki |
| Esper Boukentai: Maou no Toride | 1987 | NMK |
| Esper Dream | 1987 | Konami |
| Excitebike | 1984 | Nintendo Research & Development 1 |
| Exciting Boxing | 1987 | Human Entertainment |
| Exerion | 1983 | Tose Co., Gotch Technology Corp. |
| Exodus | 1991 | Color Dreams |
| F-1 Hero MD | 1992 | Aisystem Tokyo |
| F-1 Race | 1984 | HAL Laboratory |
| F-1 Sensation | 1993 | Konami |
| F-117A Stealth Fighter | 1992 | MicroProse |
| F-15 Strike Eagle | 1984 | MicroProse |
| F1 Circus | 1990 | Nichibutsu |
| Famicom Jump II: Saikyō no Shichinin | 1991 | Chunsoft |
| Famicom Jump: Hero Retsuden | 1989 | Tose Co. |
| Famicom Wars | 1988 | Intelligent Systems |
| Family Feud | 1991 | Krome Studios Melbourne |
| Family Jockey | 1987 | Namco |
| Family Mahjong | 1987 | Nichibutsu |
| Family Mahjong II: Shanghai he no Michi | 1988 | Nichibutsu |
| Family Quiz: Four People are Rivals | 1988 | Athena |
| Family Tennis | 1987 | Namco |
| Family Trainer Series 5: Meiro Daisakusen | 1987 | Human Entertainment |
| Family Trainer: Jogging Race | 1987 | Human Entertainment |
| Family Trainer: Totsugeki! Fuuun Takeshi Jou | 1987 | Human Entertainment |
| Famista '89: Kaimaku Ban!! | 1989 | Namco |
| Fantastic Dizzy | 1991 | Oliver Twins |
| Fantasy Zone | 1986 | Sega, Pixel, Sunsoft |