| Super Mario Bros. / Duck Hunt / World Class Track Meet | 1988 | Nintendo |
| Super Mario Bros. 2 | 1988 | Nintendo Entertainment Analysis & Development |
| Super Mario Bros. 3 | 1988 | Nintendo Entertainment Analysis & Development |
| Super Mario Bros./Tetris/Nintendo World Cup | 1988 | Nintendo |
| Super Mario Bros.: The Lost Levels | 1986 | Nintendo Entertainment Analysis & Development |
| Super Painter | 2019 | Mega Cat Studios |
| Super Pitfall | 1986 | Micronics |
| Super Real Baseball | 1988 | VAP Inc., Pax Softnica |
| Super Sprint | 1986 | Atari Games |
| Super Spy Hunter | 1991 | Sunsoft |
| Super Star Force: Jikūreki no Himitsu | 1986 | Tecmo |
| Super Team Games | 1986 | Human Entertainment |
| Super Tilt Bro. | 2024 | — |
| Super Turrican | 1992 | Rainbow Arts |
| Super Xevious: GAMP no Nazo | 1986 | Tose Co. |
| Superman | 1987 | Kemco |
| Supremacy: Your Will Be Done | 1990 | Acclaim Studios London |
| Swamp Thing | 1992 | Imagineering |
| Sword Master | 1990 | Athena |
| Swords and Serpents | 1990 | Interplay Entertainment |
| Taboo: The Sixth Sense | 1989 | Rare Ltd. |
| Tag Team Match: MUSCLE | 1985 | Tose Co. |
| Tag Team Wrestling | 1983 | Technōs Japan |
| Taito Grand Prix: Eikou heno License | 1987 | Now Production |
| Takahashi Meijin no Bug-tte Honey | 1987 | Hudson Soft |
| Takeshi no Chōsenjō | 1986 | Taito |
| Talespin | 1991 | Capcom |
| Tanigawa Kōji no Shogi Shinan II | 1987 | Pony Canyon |
| Tanigawa Kōji no Shogi Shinan III | 1989 | Pony Canyon |
| Tao | 1989 | Pax Softnica |
| Target: Renegade | 1988 | Gary Biasillo |
| Tashiro Masashi no Princess ga Ippai | 1989 | HAL Laboratory |
| Tecmo Baseball | 1989 | Tecmo |
| Tecmo Bowl | 1987 | Tecmo |
| Tecmo Cup Soccer Game | 1988 | Tecmo |
| Tecmo NBA Basketball | 1992 | Tecmo |
| Tecmo Super Bowl | 1991 | Tecmo |
| Tecmo World Cup Soccer | 1990 | Tecmo |
| Tecmo World Wrestling | 1989 | Tecmo |
| Teenage Mutant Ninja Turtles | 1989 | Konami |
| Teenage Mutant Ninja Turtles II: The Arcade Game | 1990 | Konami |
| Teenage Mutant Ninja Turtles III: The Manhattan Project | 1991 | Konami |
| Teenage Mutant Ninja Turtles: Tournament Fighters | 1993 | Konami |
| Tenchi wo Kurau II | 1991 | Capcom |
| Tenkaichi Bushi Keru Nagūru | 1988 | Game Studio |
| Tennis | 1984 | Nintendo Research & Development 1, Nintendo |
| Terminator 2: Judgment Day | 1992 | Software Creations |
| Terra Cresta | 1985 | Nichibutsu |
| Tetris | 1988 | Nintendo Research & Development 1 |
| Tetris | 1984 | Vadim Gerasimov, Vladimir Pokhilko, Alexey Pajitnov |
| Tetris 2 | 1993 | Tose Co., Nintendo Research & Development 1, Nintendo |
| Tetris 2 + Bombliss | 1991 | Chunsoft |
| Tetsuwan Atom | 1988 | Magical Company |
| The 3-D Battles of Worldrunner | 1987 | Square |
| The Addams Family | 1992 | Ocean Software |
| The Addams Family: Pugsley's Scavenger Hunt | 1992 | Ocean Software |
| The Adventures of Bayou Billy | 1988 | Konami |
| The Adventures of Gilligan's Island | 1990 | Human Entertainment |
| The Adventures of Rad Gravity | 1990 | Interplay Entertainment |
| The Adventures of Rocky and Bullwinkle and Friends | 1992 | Imagineering |