| Snake's Revenge | 1990 | Konami |
| Snoopy's Silly Sports Spectacular | 1988 | Kemco |
| Snow Bros.: Nick and Tom | 1990 | Toaplan |
| Soccer | 1985 | Intelligent Systems |
| Solar Jetman | 1990 | Zippo Games |
| Solomon's Key | 1986 | Tecmo |
| Solomon's Key 2 | 1992 | Tecmo |
| Solstice | 1990 | Software Creations |
| Somari | 1994 | Hummer Team, Dendy |
| SonSon | 1984 | Capcom |
| Space Harrier | 1985 | Sega AM2 |
| Space Hunter | 1986 | Kemco |
| Space Invaders | 1978 | Taito |
| Space Shuttle Project | 1991 | Imagineering |
| Spartan X 2 | 1991 | Irem |
| Spelunker | 1985 | MicroGraphic Image |
| Spelunker II: Yūsha e no Chōsen | 1987 | Now Production |
| Spider-Man: Return of the Sinister Six | 1992 | Bits Studios |
| Splatterhouse: Wanpaku Graffiti | 1989 | Now Production |
| Spot: The Video Game | 1990 | Visual Concepts, Virgin Interactive |
| Spy Hunter | 1983 | Midway Games |
| Spy vs. Spy | 1984 | Aackosoft, First Star Software |
| Spy vs. Spy: The Island Caper | 1985 | Aackosoft |
| Sqoon | 1986 | Magical Company |
| Square Deal: The Game of Two Dimensional Poker | 1990 | Human Engineered Software, Hect |
| Square's Tom Sawyer | 1989 | Square |
| Stack-Up | 1985 | Nintendo Research & Development 1 |
| Stadium Events | 1986 | Bandai |
| Stanley: The Search for Dr. Livingston | 1992 | Sculptured Software |
| Star Force | 1984 | Koei Tecmo Holdings |
| Star Luster | 1985 | Namco |
| Star Soldier | 1986 | Hudson Soft |
| Star Trek: 25th Anniversary | 1991 | Interplay Entertainment |
| Star Trek: The Next Generation | 1993 | Absolute Entertainment |
| Star Voyager | 1986 | ASCII Corporation |
| Star Wars | 1987 | Namco |
| Star Wars | 1991 | Lucasfilm Games, Krome Studios Melbourne, NMS Software, Tiertex Design Studios |
| Star Wars: The Empire Strikes Back | 1992 | Lucasfilm Games, Sculptured Software |
| Stargate | 1981 | Vid Kidz |
| Starship Hector | 1987 | Hudson Soft |
| StarTropics | 1990 | Nintendo Integrated Research & Development |
| Stealth ATF | 1989 | Imagineering |
| Stinger | 1986 | Konami |
| Streemerz | 2010 | — |
| Street Cop | 1987 | Human Entertainment |
| Street Fighter 2010: The Final Fight | 1990 | Capcom |
| Strider | 1989 | Capcom |
| Stunt Kids | — | Codemasters |
| Sugoro Quest: Dice Heroes | 1991 | Technōs Japan |
| Sunday Funday | 1995 | Color Dreams |
| Sunman | 1992 | EIM |
| Super Cars | 1990 | Gremlin Interactive |
| Super Chinese 3 | 1991 | Culture Brain |
| Super Contra | 1988 | Konami |
| Super Dodge Ball | 1988 | Technōs Japan |
| Super Glove Ball | 1990 | Rare Ltd. |
| Super Hydlide | 1987 | D Wonderland Inc. |
| Super Jeopardy! | 1991 | GameTek |
| Super Mario Bros. | 1985 | Nintendo Entertainment Analysis & Development |
| Super Mario Bros. / Duck Hunt | 1986 | Nintendo |