| Saint Seiya: Ougon Densetsu Kanketsu Hen | 1988 | Tose Co. |
| Saiyūki World | 1988 | NMK |
| Salamander | 1986 | Konami |
| Sangokushi | 1988 | Tose Co. |
| Sanma no Meitantei | 1987 | Namco |
| Sanrio Cup: Pon Pon Volley | 1992 | Character Soft |
| Sansū 2-nen: Keisan Game | 1986 | Tokyo Shoseki |
| Sasa | 1985 | MTL |
| Satoru Nakajima F-1 Hero 2 | 1991 | Human Entertainment |
| SD Battle Oozumou: Heisei Hero Basho | 1990 | Banpresto |
| SD Gundam Gaiden: Knight Gundam Monogatari | 1990 | Tose Co. |
| SD Gundam Gaiden: Knight Gundam Monogatari 2 - Hikari no Kishi | 1991 | Bandai |
| SD Gundam Gaiden: Knight Gundam Monogatari 3 - Densetsu no Kishi Dan | 1992 | Bandai |
| SD Gundam World: Gachapon Senshi - Scramble Wars - Map Collection | 1989 | Bandai |
| SD Gundam World: Gachapon Senshi 2 - Capsule Senki | 1989 | Opera House, Human Entertainment, Bandai |
| SD Gundam World: Gachapon Senshi 3 - Eiyuu Senki | 1990 | Opera House, Bandai |
| SD Gundam World: Gachapon Senshi 4 - New Type Story | 1991 | Tose Co., Bandai |
| SD Gundam World: Gachapon Senshi 5 - Battle of Universal Century | 1992 | Tose Co., Bandai |
| SD Gundam: Gundam Wars | 1993 | Bandai |
| SD Hero Sōkessen: Taose Aku no Gundan | 1990 | Interlink Computer Sciences |
| Secret Scout in the Temple of Demise | — | Color Dreams |
| Section Z | 1985 | Capcom |
| Seicross | 1984 | Nichibutsu |
| Seikima II Akuma no Gyakushū! | 1986 | ISCO |
| Sekiryūō | 1989 | Sunsoft |
| Sesame Street Countdown | 1992 | Running with Scissors |
| Sesame Street Letters | 1989 | Rare Ltd. |
| Sesame Street: A-B-C/1-2-3 | 1991 | Rare Ltd. |
| Sesame Street: Numbers Count | 1989 | Rare Ltd. |
| Shadow Brain | 1991 | Scitron & Art Inc. |
| Shadow of the Ninja | 1990 | Winning Entertainment Group |
| Shadowgate | 1987 | ICOM Simulations |
| Shanghai | 1986 | Sunsoft |
| Shatterhand | 1991 | Winning Entertainment Group |
| Sherlock Holmes: Hakushaku Reijō Yūkai Jiken | 1986 | Towa Chiki |
| Shikinjoh | 1991 | Sunsoft |
| Shingen the Ruler | 1989 | Another |
| Shinobi | 1987 | Sega |
| Shockwave | 1990 | American Game Cartridges |
| Shooting Range | 1989 | Tose Co. |
| Short Order / Eggsplode! | 1989 | Tose Co. |
| Shuffle Fight | 1992 | Pandora Box |
| Shufflepuck Café | 1989 | Broderbund |
| Sid Meier's Pirates! | 1987 | MicroProse |
| Side Pocket | 1986 | Data East |
| Silent Assault | 1990 | Thin Chen Enterprise |
| Silent Service | 1985 | MicroProse |
| Silk Worm | 1988 | Tecmo |
| Silver Surfer | 1990 | Software Creations |
| Sim City | 1991 | Electronic Arts |
| Sir Ababol | 2012 | — |
| Skate or Die 2: The Search for Double Trouble | 1990 | Electronic Arts |
| Skate or Die! | 1987 | Electronic Arts |
| Ski or Die | 1990 | Electronic Arts |
| Skull & Crossbones | 1987 | Atari Games |
| Sky Destroyer | 1985 | Magical Company |
| Sky Kid | 1985 | Namco |
| Slalom | 1987 | Rare Ltd. |
| Smash TV | 1990 | WMS Industries |
| Snake Rattle 'n' Roll | 1990 | Rare Ltd. |