| Super Wagan Land | 1991 | — |
| Super Widget | 1993 | — |
| Super Wrestle Angels | 1994 | — |
| Super Ōzumō: Netsusen Daiichiban | 1992 | Namco |
| Sutobasu Yarō Shō | 1994 | KID |
| Sutte Hakkun | 1997 | Nintendo Research & Development 2 |
| Suzuka 8 Hours | 1992 | Arc System Works |
| SWAT Kats: The Radical Squadron | 1995 | Fortyfive |
| SWIV | 1991 | — |
| Sword World SFC | 1993 | — |
| Syndicate | 1993 | Bullfrog Productions |
| Syvalion | 1988 | Taito |
| Tactical Soccer | 1995 | — |
| Tactics Ogre: Let Us Cling Together | 1995 | Quest |
| Tadaima Yuusha Boshuuchuu Okawari | 1994 | Human Entertainment |
| Taekwon-Do | 1994 | — |
| Taiko Risshiden | 1992 | Koei |
| Take Yutaka G1 Memory | 1995 | Gaps |
| Takeda Nobuhiro no Super League Soccer | 1994 | Tose Co. |
| Tales of Phantasia | 1995 | Namco Tales Studio |
| Tarot Mystery | 1995 | Ukiyotei |
| Taz-Mania | 1992 | NuFX |
| Tecmo Super Baseball | 1994 | Tecmo |
| Tecmo Super Bowl | 1991 | Tecmo |
| Tecmo Super Bowl II: Special Edition | 1994 | Tecmo |
| Tecmo Super Bowl III: Final Edition | 1995 | Tecmo |
| Tecmo Super NBA Basketball | 1992 | Tecmo |
| Teenage Mutant Ninja Turtles IV: Turtles in Time | 1992 | — |
| Teenage Mutant Ninja Turtles: Tournament Fighters | 1993 | Konami |
| Teenage Mutant Ninja Turtles: Turtles in Time | 1991 | Konami |
| Tenchi Muyo! Game Hen | 1995 | Banpresto |
| Tengai Makyō Zero | 1995 | Red Entertainment |
| Terminator 2 | 1993 | — |
| Terminator 2: Judgment Day | 1991 | Midway Games |
| Terranigma | 1995 | Quintet |
| Tetris & Dr. Mario | 1994 | Intelligent Systems |
| Tetris 2 | 1993 | Tose Co., Nintendo Research & Development 1, Nintendo |
| Tetris Attack | 1995 | Intelligent Systems |
| Tetris Battle Gaiden | 1993 | Bullet-Proof Software |
| Tetsuwan Atom | 1994 | — |
| The 7th Saga | 1993 | Produce! |
| The Addams Family | 1992 | Ocean Software |
| The Adventures of Batman & Robin | 1994 | Konami |
| The Adventures of Mighty Max | 1994 | — |
| The Adventures of Rocky and Bullwinkle and Friends | 1992 | Imagineering |
| The Adventures of Tintin: Prisoners of the Sun | — | Infogrames |
| The Amazing Spider-Man: Lethal Foes | 1995 | — |
| The Aquatic Games Starring James Pond and the Aquabats | 1992 | — |
| The Atlas | 1991 | Artdink |
| The Blue Crystal Rod | 1994 | GAME STUDIO Inc. |
| The Blues Brothers: Jukebox Adventure | 1993 | — |
| The Brainies | 1991 | — |
| The Chaos Engine | 1993 | The Bitmap Brothers |
| The Combatribes | 1990 | Technōs Japan |
| The Death and Return of Superman | 1994 | Blizzard Entertainment |
| The Duel: Test Drive II | 1989 | Distinctive Software |
| The Firemen | 1994 | Human Entertainment |
| The Flintstones | 1995 | Ocean Software |
| The Flintstones: The Treasure of Sierra Madrock | 1994 | Taito |
| The Great Battle Gaiden 2: Matsuri da Wasshoi | 1994 | — |