| Mission Cobra | 1990 | Thin Chen Enterprise |
| Mission: Impossible | 1990 | Konami |
| Mitsume ga Tooru | 1992 | Winning Entertainment Group |
| Moai-kun | 1990 | Konami |
| Mobile Suit Z Gundam: Hot Scramble | 1986 | Game Studio |
| Moero 6!! Shin Moero!! Pro Yakyuu | 1989 | Jaleco |
| Moero 7!! Juudou Warriors | 1990 | Jaleco |
| Momoko 120% | 1986 | Jaleco |
| Momotaro Dentetsu | 1988 | Hudson Soft |
| Monopoly | 1991 | Sculptured Software |
| Monster in My Pocket | 1992 | Konami |
| Monster Party | 1989 | Human Entertainment |
| Monster Truck Rally | 1991 | Realtime Associates |
| Moon Crystal | 1992 | Hect |
| Moon Ranger | 1990 | Odyssey Software |
| Mortal Kombat II Special | 2000 | Hummer Team |
| Mother | 1989 | Nintendo |
| Motor City Patrol | 1992 | Source Research & Development |
| MotoRace USA | 1983 | Irem |
| Ms. Pac-Man | 1982 | Midway Games |
| Multidude | 2019 | Mega Cat Studios |
| Muppet Adventure: Chaos at the Carnival | 1990 | Minds Eye Entertainment |
| Murder on the Mississippi | 1986 | Activision |
| Musashi no Bōken | 1990 | Quest |
| Musashi no Ken – Tadaima Shugyō Chū | 1986 | Taito |
| My Life My Love: Boku no Yume: Watashi no Negai | 1991 | Winkysoft |
| Mystery Quest | 1987 | Carry Lab |
| Mystery Tower | 1986 | Namco |
| Nadia: The Secret of Blue Water | 1991 | Advance Communication |
| Nagagutsu o Haita Neko: Sekai Isshū 80 Nichi Dai Bōken | 1986 | Shōei |
| Nakayoshi to Issho | 1993 | Yutaka |
| Nantettatte!! Baseball | 1990 | Sunsoft |
| Napoleon Senki | 1988 | Lenar |
| Narc | 1988 | WMS Industries |
| Nebulus | 1987 | Triffix Entertainment |
| Nekketsu Kakutō Densetsu | 1992 | Technōs Japan |
| Nekketsu Street Basket: Ganbare Dunk Heroes | 1993 | Technōs Japan |
| NES Open Tournament Golf | 1991 | Nintendo Research & Development 2 |
| NES Play Action Football | 1990 | Tose Co. |
| NEScape! | 2019 | — |
| New Ghostbusters II | 1990 | HAL Laboratory |
| NFL | 1989 | Atlus |
| Nigel Mansell's World Championship Racing | 1993 | Gremlin Interactive |
| Nightshade | 1992 | Krome Studios Melbourne |
| Niji no Silkroad | 1991 | NHK |
| Ninja Crusaders | 1990 | NMK |
| Ninja Gaiden | 1988 | Tecmo |
| Ninja Gaiden II: The Dark Sword of Chaos | 1990 | Tecmo |
| Ninja Gaiden III: The Ancient Ship of Doom | 1991 | Tecmo |
| Ninja Hattori-kun | 1986 | Hudson Soft |
| Ninja JaJaMaru-kun | 1985 | Tose Co. |
| Ninja Kid | 1986 | Tose Co. |
| Ninja-Kid | 1984 | Universal Entertainment, UPL |
| Nintendo Campus Challenge 1991 | 1991 | Nintendo |
| Nintendo Campus Challenge 1992 | 1992 | Nintendo |
| Nintendo World Cup | 1990 | Technōs Japan |
| Noah's Ark | 1992 | Source Research & Development |
| Nobunaga's Ambition | 1986 | Koei Tecmo Games |
| North & South | 1989 | Infogrames |
| Nuts & Milk | 1984 | Hudson Soft |