| Earth Defense Force | 1991 | Jaleco |
| Earth Light | 1992 | Hudson Soft |
| EARTH LIGHT LUNA STRIKE | 1996 | — |
| EarthBound | 1994 | HAL Laboratory, Creatures |
| EarthBound 64 | 2000 | Nintendo |
| EarthBound Halloween Hack | 2008 | — |
| Earthworm Jim | 1994 | Shiny Entertainment |
| Earthworm Jim 2 | 1995 | Shiny Entertainment |
| Edo no Kiba | 1993 | Riot |
| Eek! The Cat | 1994 | — |
| Elfaria | 1993 | Hudson Soft, Red Entertainment |
| Elfaria II: The Quest of the Meld | 1995 | — |
| Elite Soccer | 1994 | — |
| Emerald Dragon | 1995 | Alfa System |
| Emit | 1994 | Koei |
| Emmitt Smith Football | 1995 | — |
| Energy Breaker | 1996 | Neverland |
| Equinox | 1993 | Software Creations |
| ESPN Baseball Tonight | 1994 | Park Place Productions |
| ESPN National Hockey Night | 1994 | Sony Imagesoft |
| ESPN SpeedWorld | 1994 | Park Place Productions |
| ESPN Sunday Night NFL | 1994 | Absolute Entertainment |
| Eternal Filena | 1995 | Tokuma Shoten |
| Extra Innings | 1991 | Sting |
| Eye of the Beholder | 1990 | Strategic Simulations, Westwood Studios |
| F - ZERO | 1990 | — |
| F-1 Grand Prix | 1991 | Video System |
| F-1 Grand Prix Part II | 1992 | Video System |
| F-1 Grand Prix Part III | 1994 | Video System |
| F-Zero | 1990 | Nintendo Entertainment Analysis & Development |
| F1 Pole Position | 1992 | Human Entertainment |
| F1 Pole Position 2 | 1993 | Human Entertainment |
| F1 ROC II: Race of Champions | 1993 | SETA Corporation |
| F1 ROC: Race of Champions | 1992 | SETA Corporation |
| Famicom Bunko: Hajimari no Mori | 1999 | — |
| Famicom Tantei Club Part II: Ushiro ni Tatsu Shōjo | 1989 | Tose Co. |
| Family Feud | 1993 | Imagineering |
| Fatal Fury 2 | 1992 | SNK |
| Fatal Fury Special | 1993 | SNK |
| Fatal Fury: King of Fighters | 1991 | SNK |
| Feda: The Emblem of Justice | 1994 | — |
| Feudal Bros: Tonosama #1 | 1995 | — |
| Fever Pitch Soccer | 1995 | U.S. Gold |
| FIFA 97 | 1996 | EA Vancouver |
| FIFA International Soccer | 1993 | EA Vancouver |
| FIFA Soccer 96 | 1995 | Acclaim Studios London |
| FIFA: Road to World Cup 98 | 1997 | EA Vancouver |
| Fighter's History | 1993 | — |
| Fighter's History: Mizoguchi Kiki Ippatsu !! | 1995 | — |
| Final Fantasy IV | 1991 | Square |
| Final Fantasy Mystic Quest | 1992 | Square |
| Final Fantasy V | 1992 | Square |
| Final Fantasy VI | 1994 | Square |
| Final Fight | 1989 | Capcom |
| Final Fight 2 | 1993 | Capcom |
| Final Fight 3 | 1995 | Capcom |
| Final Set | 1993 | — |
| Final Stretch | 1993 | Genki |
| Fire Emblem: Genealogy of the Holy War | 1996 | Intelligent Systems |
| Fire Emblem: Mystery of the Emblem | 1994 | Intelligent Systems |