| Shakedown: Hawaii | 2019 | Vblank Entertainment |
| Shantae | 2002 | WayForward Technologies |
| Shantae and the Pirate's Curse | 2014 | WayForward Technologies |
| Sherlock Holmes and the Mystery of the Frozen City | 2012 | Frogwares |
| Shifting World | 2012 | — |
| Shin Megami Tensei IV | 2013 | Atlus |
| Shin Megami Tensei IV: Apocalypse | 2016 | Atlus |
| Shin Megami Tensei: Devil Survivor 2 Record Breaker | 2015 | — |
| Shin Megami Tensei: Devil Survivor Overclocked | 2011 | — |
| Shin Megami Tensei: Strange Journey Redux | 2017 | Atlus |
| Shinobi | 2011 | Griptonite Games |
| Shoot the Ball | 2016 | RCMADIAX |
| Shovel Knight | 2014 | Yacht Club Games |
| Shovel Knight: Specter of Torment | 2017 | Yacht Club Games |
| Shovel Knight: Treasure Trove | 2014 | Yacht Club Games |
| Skylanders: Giants | 2012 | Toys for Bob |
| Skylanders: Spyro's Adventure | 2011 | Toys for Bob |
| Skylanders: Swap Force | 2013 | Blizzard Albany |
| Skylanders: Trap Team | 2014 | Toys for Bob |
| Slice It! | — | Com2uS |
| Slime Mori Mori Dragon Quest 3 | 2011 | Square Enix |
| Sonic & All-Stars Racing Transformed | 2012 | Sumo Digital |
| Sonic Boom | 2014 | — |
| Sonic Boom: Fire & Ice | 2016 | Sanzaru Games |
| Sonic Boom: Shattered Crystal | 2014 | Sanzaru Games |
| Sonic Generations | 2011 | Sonic Team, Dimps |
| Sonic Lost World | 2013 | Sonic Team |
| Sonic the Hedgehog | 1991 | Sonic Team, Konami |
| Sonic the Hedgehog 2 | 1992 | Sonic Team |
| Sonic the Hedgehog 3 | 1994 | Sonic Team |
| Space Harrier | 1985 | Sega AM2 |
| Space Intervention | 2021 | — |
| Spider-Man: Edge of Time | 2011 | Beenox |
| Spirit Camera: The Cursed Memoir | 2012 | Koei Tecmo Holdings |
| SpongeBob HeroPants | 2015 | Behaviour Interactive |
| SpongeBob SquarePants: Plankton's Robotic Revenge | 2013 | Behaviour Interactive |
| SpongeBob SquigglePants | 2011 | WayForward Technologies |
| Sports Island 3D | 2011 | — |
| Spy Hunter | 2012 | TT Fusion |
| Squids Odyssey | 2014 | The Game Bakers |
| Star Fox 64 3D | 2011 | Q-Games, Nintendo Entertainment Analysis & Development |
| Stardew Valley | 2016 | ConcernedApe LLC, Eric Barone |
| SteamWorld Dig | 2013 | Image & Form |
| SteamWorld Dig 2 | 2017 | Image & Form |
| SteamWorld Heist | 2015 | Image & Form |
| Steel Diver | 2011 | Nintendo Entertainment Analysis & Development |
| Steel Diver: Sub Wars | 2014 | Nintendo |
| Stella Glow | 2015 | Imageepoch |
| Storm Chaser: Tornado Alley | 2018 | Skunk Software |
| Story of Seasons | 2014 | Marvelous |
| Story of Seasons: Trio of Towns | 2016 | Marvelous |
| Street Fighter 2010: The Final Fight | 1990 | Capcom |
| StreetPass Mii Plaza | 2011 | Nintendo Software Planning & Development |
| Stretchmo | 2015 | Intelligent Systems |
| Style Savvy: Fashion Forward | 2015 | Syn Sophia |
| Style Savvy: Styling Star | 2017 | Syn Sophia |
| Style Savvy: Trendsetters | 2012 | Syn Sophia |
| Super Mario 3D Land | 2011 | Nintendo Entertainment Analysis & Development, EAD Tokyo, Bauhaus Entertainment |
| Super Mario Maker for Nintendo 3DS | 2016 | Nintendo |
| Super Monkey Ball 3D | 2011 | Amusement Vision |